Endocrine Abstracts

Introduction: Androgen excess in women usually is presented as hirsutism and alopecia. Androgens could be expressed from adrenal or ovarian origin.Case reports: Female, 57 years (yrs) old, presented with hirsutism (Ferriman Galwey score, FGS 18), weight gain, type 2 diabetes mellitus (DM2), hypertension, hyperlipidemia and obesity (BMI 38.5 kg/m2). Diagnostic evaluation revealed normal prolactin, SHBG, DHEAS, IGF-1, ACTH, TSH, serum cortisol i...

Introduction: Endocrinopathies are rare causes of erectile dysfunction and previously cases of hyperprolactinaemia and pituitary adenomas have been reported.Case report: We present the clinical case of a 27-year old male, married for 4 years with no children, presented with possible infertility and erectile dysfunction which was previously interpreted as caused by a poor social and psychological situation in the family. After additional endocrinological ...

Aim of the study: The main objectives were to determine incidence and type of anemia in patients with type 2 diabetes and the differences considering gender, age and duration of type 2 diabetes.Material and methods: The research was structured as a cross-sectional research with historical data. The research used data collected during regular check-ups in primary health care clinics in the Osijek Health Center, Croatia, from April to June 2023. Collected ...

Introduction: PCSK-9 (proprotein convertase subtilisin/kexin type 9) inhibitors are monoclonal antibodies that affect metabolism of low-density lipoprotein (LDL) by binding to the LDL receptor and promoting lysosomal degradation. There are two pcsk-9 inhibitors currently available: alirocumab (Praulent) and evolocumab (Repatha) which are administered subcutaneously every 14 days. Two large randomized studies (FOURIER, ODYSSEY) have shown that pcsk-9 inhibitors reduce LDL-chole...

Aim of the study: The objectives of this study were to determine the regulation of glycemia (measured by fasting glucose levels and HbA1c) in patients with type 2 diabetes and to examine whether there is a difference in therapy (oral antidiabetics, insulin, combination), age, sex and BMI.Study design: Cross-sectional research with historical data.Patients: The study included 102 patients of both sexes (56% women and 44% men) with a...

Aim of the Study: The main objectives were to examine the incidence of hyperlipoproteinemia in postmenopausal women and to determine the differences in lipid profile considering age, duration of menopause and body mass index in postmenopausal women.Material and Methods: The research was structured as a cross-sectional research with historical data. The research used data collected during regular check-ups in primary health care clinics in the Osijek Heal...

Introduction: Depression is the leading cause of disability worldwide, and is a major contributor to the overall global burden of disease. People with DM have 2.4–4.3 times greater risk of depression than people without DM as well as patients (pts) treated with insulin. Women experience depression more often than men. Symptoms of depression can make it more difficult to successfully manage diabetes and prevent diabetes-related complications.Material...

Introduction: In patients with non-controlled type 2 diabetes mellitus (DM2) and obesity treated with oral therapy, liraglutide treatment should improve glycemic and metabolic control.Materials and methods: Retrospective descriptive study. Liraglutide treatment was started in 46 outpatients with uncontrolled DM2. The effect of therapy was evaluated between September 2013 and January 2016. Age, sex, duration of diabetes, weight, BMI, HbA1c, fasti...

Aim: Dopamine agonist (DA) therapy is recommended as first-line treatment for prolactinomas, albeit with long treatment duration and high recurrence rate after treatment withdrawal. The aim of this retrospective study was to evaluate predictors for successful DA withdrawal.Methods: The study included 59 prolactinoma patients (39 female, 20 male; age 34 (18–82) years) that were treated with DA (35.6% on cabergoline); the duration of treatment was 71 ...

Background: Primary aldosteronism (PA) is the most frequent cause of endocrine hypertension associated with excess aldosterone production from one or both adrenal glands. Somatic or germline mutations in the KCNJ5 potassium channel cause an imbalance in intracellular ion homeostasis. This ultimately drives aldosterone overproduction in some sporadic forms of PA and a familial form of the disease (familial hyperaldosteronism type 3). Our objective was to identify small molecule...